Dexamphetamine effects on prepulse inhibition (PPI) and startle in healthy volunteers
نویسندگان
چکیده
منابع مشابه
Effects of melatonin on prepulse inhibition, habituation and sensitization of the human startle reflex in healthy volunteers.
Prepulse inhibition of the startle reflex (PPI) is an operational measure of sensorimotor gating, which is demonstrated to be impaired in patients with schizophrenia. In addition, a disruption of the circadian rhythm together with blunted melatonin secretion is regularly found in patients with schizophrenia and it is theorized that these may contribute to their attentional deficits. The aim of ...
متن کاملPrepulse-elicited startle in prepulse inhibition.
BACKGROUND Prepulse inhibition (PPI) has become a major experimental paradigm in the study of psychiatric disorders. In this study, a potential confound in measurement and interpretation of PPI, namely startle reactions to so-called "nonstartling" prepulses, was examined. METHODS Prepulses of 80, 85, and 90 dB(A) were presented on their own or followed by a pulse of 115 dB(A) (lead interval: ...
متن کاملHypnotizability, Hypnosis and Prepulse Inhibition of the Startle Reflex in Healthy Women: An ERP Analysis
A working model of the neurophysiology of hypnosis suggests that highly hypnotizable individuals (HHs) have more effective frontal attentional systems implementing control, monitoring performance, and inhibiting unwanted stimuli from conscious awareness, than low hypnotizable individuals (LHs). Recent studies, using prepulse inhibition (PPI) of the auditory startle reflex (ASR), suggest that HH...
متن کاملHabituation and prepulse inhibition of acoustic startle in rodents.
The acoustic startle response is a protective response, elicited by a sudden and intense acoustic stimulus. Facial and skeletal muscles are activated within a few milliseconds, leading to a whole body flinch in rodents(1). Although startle responses are reflexive responses that can be reliably elicited, they are not stereotypic. They can be modulated by emotions such as fear (fear potentiated s...
متن کاملDiscrete and continuous prepulses have differential effects on startle prepulse inhibition and skin conductance orienting.
The effectiveness of different types of auditory prepulses in eliciting skin conductance orienting and in producing prepulse inhibition (PPI) of the acoustic startle eyeblink was studied in two experiments. A discrete white noise prepulse produced greater PPI than either a continuous white noise, a discrete tone, or a continuous tone. The discrete white noise advantage was not due to similarity...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2013
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-013-3395-z